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The Killer’s Game follows veteran assassin Joe Flood (Bautista), who is diagnosed with a life-threatening illness and authorizes a kill on himself to avoid the pain that is destined to follow. After ordering the kill, he finds out that he was misdiagnosed and must then fend off the army of former colleagues trying to kill him.

The sequel picks up with Big Nick tracking down bad guys on the streets of Europe and getting closer to capturing Donnie (Jackson). Donnie, meanwhile, has become caught up in the dangerous world of diamond thieves and the Panther mafia, as a heist on the world's largest diamond exchange is being planned.

Story follows Alex (Sandra Bullock), an American who has fallen on hard times, who starts a job at a London armored car company that was the recent target of a deadly heist. She works her way into the confidence of the tight-knit crew and we discover that there is much more to Alex than it seems. As she goes to dangerous and morally complicated lengths to pursue her own mysterious agenda, an explosive secret from Alex’s past surfaces propelling the story in shocking, thrilling new directions‎.