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In honor of Rebecca's (Rachel Dratch) 50th birthday, Abby (Amy Poehler) plans a scenic Napa getaway with their best, longtime friends. Workaholic Catherine (Ana Gasteyer), post-op Val (Paula Pell), homebody Jenny (Emily Spivey), and weary mom Naomi (Maya Rudolph) are equally sold on the chance to relax and reconnect. Yet as the alcohol flows, real world uncertainties intrude on the punchlines and gossip, and the women begin questioning their friendships and futures.

Jack Gladney is the world expert on Hitler Studies. He is afraid of death. His wife Babette is also afraid of death. In this black comedy, Jack must deal with death, air born toxic events, mysterious pills and the strange complexities that make up life.